![]() Case 1Ī 16-year-old-male presented with a history of fever, weakness, headache with photophobia, abdominal pain, vomiting, and axillar lymphadenopathy. All patients and/or parents provided informed consent for publication of the cases. We present three patients with overlapping features of KD and SLE. SLE can present coronary arteritis with aneurysm formation ( 4). Vasculitis in lupus is most commonly due to the local deposition of immune complexes, but some patients have an inflammatory vasculopathy in the absence of local immune complex deposition ( 3). ![]() Kawasaki disease (KD) and systemic lupus erythematosus (SLE) are immune mediated diseases characterized by varied clinical features that may include vasculitis ( 1– 3). An adolescent with fever and rash should include KD and SLE in the differential diagnosis. KD in adolescence presents with atypical signs, incomplete presentation, and develop coronary complications more commonly. Lessons: Both diseases may mimic each other's clinical presentation. The second patient was treated with IVIG, corticosteroids and methotrexate and the third patient with IVIG, aspirin and corticosteroids. Interventions: The first patient was treated with IVIG, corticosteroids, aspirin, coumadin and mycophenolate mofetil. Patient concerns: We present three adolescents, one with fever, rash, arthritis, nephritis, lymphopenia, and coronary aneurysms, a second patient with rash, fever, aseptic meningitis, and seizures, and a third patient with fever, rash, and pleural effusion.ĭiagnoses: The first patient was finally diagnosed with SLE and KD, the second patient initially diagnosed as KD but eventually SLE and the third patient was diagnosed at onset as lupus but finally diagnosed as KD. Coexistence of both diseases is also possible. There have been case reports of lupus onset mimicking KD and KD presenting as lupus-like. Their presentation is varied and not always straightforward, leading to misdiagnosis. Rationale: Kawasaki disease (KD) is an acute vasculitis of small and medium vessels whereas systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease. 4Department of Cardiology, Instituto Nacional de Pediatría, Mexico City, Mexico.3Department of Clinical Immunology, Instituto Nacional de Pediatría, Mexico City, Mexico.2Department of Pediatrics, Instituto Nacional de Pediatría, Mexico City, Mexico. ![]() 1Department of Dermatology, Instituto Nacional de Pediatría, Mexico City, Mexico.Marimar Saez-de-Ocariz 1, María José Pecero-Hidalgo 2, Francisco Rivas-Larrauri 3, Miguel García-Domínguez 3, Edna Venegas-Montoya 3, Martín Garrido-García 4 and Marco Antonio Yamazaki-Nakashimada 3 *
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